和记app下载网址

【中国科技网】《柳叶刀》发布和记app下载网址中国生物新冠灭活疫苗I/II期临床试验结果

发布时间:2020-10-16 来源: 阅读次数:212

ZHUANZIZHONGGUOKEJIWANG:http://www.stdaily.com/index/kejixinwen/2020-10/16/content_1028723.shtml

       KEJIRIBAOJIZHE JUJIAN

       JU和记app下载网址JITUANZHONGGUOSHENGWUZUIXINXIAOXI,10YUE16RI,GUOJIYIXUEXUESHUQIKAN《LIUYEDAO》(The Lancet)KANDENGLEQISUOSHUBEIJINGSHENGWUZHIPINYANJIUSUOHEZHONGGUOJIBINGYUFANGKONGZHIZHONGXINLIANHEYANZHIDEXINGUANMIEHUOYIMIAOI/IIQILINCHUANGSHIYANJIEGUO。ZHEISHIJIWUHANSHENGWUZHIPINYANJIUSUOZAIGUOJIYIXUEQIKAN《MEIGUOYIXUEHUIZAZHI》FABUQUANQIUSHOUPIANXINGUANMIEHUOYIMIAOLINCHUANGSHIYANSHUJUHOU,ZHONGGUOSHENGWUFABUDEYOUYIXINGUANMIEHUOYIMIAOLINCHUANGSHIYANSHUJU。

       GAIXIANGYANJIUYOUZHONGGUOSHENGWUDONGSHIZHANGYANGXIAOMINGYANJIUYUANHEHENANSHENGJIKONGZHONGXINXIASHENGLIZHURENYISHILINGXIAN,和记app下载网址ZHONGGUOSHENGWUJISUOSHUBEIJINGSHENGWUZHIPINYANJIUSUO、HENANSHENGJIBINGYUFANGKONGZHIZHONGXIN、ZHONGGUOSHIPINYAOPINJIANDINGYANJIUYUAN、ZHONGGUOJIBINGYUFANGKONGZHIZHONGXINDENGDUOJIAJIGOUWANCHENG,YANGXIAOMINGYANJIUYUANHEGUOWANSHENJIAOSHOUWEIWENZHANGGONGTONGTONGXUNZUOZHE,XIASHENGLIZHURENYISHI、ZHANGYUNTAOBOSHIHEWANGHUIYANJIUYUANDENGWEIGONGTONGDIYIZUOZHE。

▲ZAIGUOJIYIXUEXUESHUQIKAN《LIUYEDAO》KANZAI

       GAIXIANGSUIJI、SHUANGMANG、ANWEIJIDUIZHAODEI/IIQISHIYAN,ZAIJIEDUAN1ZHONG,JIANG192MINGJIANKANGCHENGRENFENWEI18-59SUIZUHE≥60SUIZU,YIPINGGUDI、ZHONG、GAOJILIANGYIMIAO。MEIGEZUZHONGDECANYUZHEANZHAO3:1SUIJIFENPEI,FENBIEJIEZHONGYIMIAOHUOANWEIJI。ZAIDI2JIEDUANZHONG,JIANG448WEIJIANKANGCHENGREN(18-59SUI)FENPEIDAOSIGEZUZHONG,FENBIEZAIDI0TIANJIESHOUGAOJILIANGYIMIAO,HUOZAI0/14、0/21TIANHUO0/28TIANJIESHOUZHONGDENGJILIANGYIMIAO,ZHUYAOPINGGUANQUANXINGHENAISHOUXING,CIYAOJIEGUOSHIMIANYIYUANXING,PINGGUWEIZHENDUICHUANRANXINGSARS-CoV-2DEZHONGHEKANGTIFANYING。

       有效诱导产生中和抗体

       具有良好的免疫原性

       DUIHOUXUANYIMIAOYOUDAODEZHONGHEKANGTIJIYANGZHUANLVYANJIUJIEGUOXIANSHI,ⅠQILINCHUANGZHONG,JIANKANGCHENGRENZUZHONG,JIEZHONGDIJILIANGHEZHONGJILIANGDERENQUNXUEQINGZHUANHUALVZAIDI14TIANSHIJUNDADAO100%,JIEZHONGGAOJILIANGRENQUNDEXUEQINGZHUANHUALVZAIDI14TIANSHIDADAOLE96%。LAONIANZUZHONG,SUOYOURENQUNDEXUEQINGZHUANHUALVZAIDI28TIANJUNDADAO100%。SUOYOUZUZHONG,ZHONGHEKANGTICONGDI7TIANKAISHIXIANZHEZENGJIA,DI42TIANDADAOFENGZHI。GAOJILIANGZUYIMIAOYINQIDEZHONGHEKANGTIXIAOJIAMINGXIANGAOYUDIJILIANGZU,DANYUZHONGJILIANGZUWUMINGXIANCHAYI。CIWAI,YIMIAOYINQIDEZHONGHEKANGTIKEYIZHONGHEDUOZHONGBINGDUZHU,BAOKUODANGQIANDAIYOUTUBIANTIDEDALIUXINGZIRANBIANYIZHU(D614G)。ⅡQILINCHUANGJIEGUOXIANSHI,ZAID0/D14HED0/D21CHENGXUZHONG,ZHONGHEKANGTICONGDIERCIJIEZHONGHOUDEDI14TIANDAODI28TIANZENGJIA。D0/D21CHENGXUZHONGYIMIAOYINQIDEZHONGHEKANGTIDIDUXIANZHUGAOYUD0 /D14CHENGXUZHONGYIMIAOCHANSHENGDEZHONGHEKANGTIXIAOJIA。

       ZHEIYIJIEGUOBIAOMING,GAIYIMIAONENGZAIGAINIANLINGZURENQUNZHONGYOUXIAOYOUDAOCHANSHENGZHONGHEKANGTI,ZHONGHEKANGTISHUIPINGYEYUQITAYIMIAOYANJIUBAODAODESHUIPINGXIANGDANG,ZHENGSHILEGAIYIMIAOJUYOULIANGHAODEMIANYIYUANXING。

       在人体安全性好

       ZAIANQUANXINGFANGMIAN,LIANGZHENYIMIAOJIEZHONGHOUDEQIAN7TIANNEI,YOU42MING(ZHANBI30%)JIEZHONGZHECHUXIANBULIANGFANYING,ZHUYAOSHIZHUSHEBUWEITENGTONG,QICISHIFARE,DANJUNWEIQINGWEIHEZIXIANSHIDE,BUXURENHEZHILIAO。YANJIUZHONGWURENHEYUYIMIAOYOUGUANDEYANZHONGBULIANGSHIJIANFASHENG。QIZHONGCHUXIANZHUSHEBUWEITENGTONGDEYOU34REN(ZHANBI24%),CHUXIANFAREDEYOU5REN(5%)。

       BULIANGFANYINGFASHENGLVZAIYIMIAOZUHEANWEIJIZUJIANCHAYIWUTONGJIXUEYIYI,QIEDIYUMUQIANFABIAODEYIMIAOLINCHUANGYANJIUSUOBAODAODESHUIPING,SHUOMINGGAIMIEHUOYIMIAOZAIRENTIANQUANXINGHAO。

       Ⅲ期临床试验正在有序进行

       BEIJINGSHENGWUZHIPINYANJIUSUOYANFADEXINGUANMIEHUOYIMIAOYU4YUE27RIHUOGUOJIAYAOJIANJULINCHUANGSHIYANPIJIANBINGTONGBUQIDONGⅠ/ⅡQILINCHUANGSHIYAN。

       MUQIAN,ZHONGGUOSHENGWUSUOSHUBEIJINGSHENGWUZHIPINYANJIUSUOHEWUHANSHENGWUZHIPINYANJIUSUODELIANGGEXINGUANMIEHUOYIMIAOZHENGZAIALIANQIU、BALIN、AIJI、MOLUOGE、MILU、AGENTINGDENGGUOJIAYOUXUTUIJINⅢQILINCHUANGSHIYAN,YANGBENRENQUNXIANYIFUGAI125GEGUOJI,GEFANGMIANJINZHANJUNQUANQIULINGXIAN。

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